To achieve more efficient, cost-effective, and widescale serological testing, the objective of this study was to compare the performance of a rapid point-of-care antibody test, the BioMedomics COVID-19 IgM/IgG Rapid Test [11], to a high-quality, validated, laboratory-based and automated assay, the Roche Elecsys Anti SARS-CoV-2 platform [12, 13], one of the most extensively used and investigated commercial platforms, having a specificity ≥99.8% [14, 15] and a sensitivity ≥89% [12, 14]. This evidence concerns the gene CD40LG and COVID-19.