EPHB2 and hemorrhagic disease: EPHB3 encodes ephrin receptor B3, and plays roles in development, cell migration, and adhesion; variants in family member EPHB2, which also binds ephrin-B family ligands, are associated with a Mendelian bleeding disorder characterized by deficiencies in agonist-induced platelet aggregation and granule secretion (OMIM 600997 [31]).