Multiple pathways are implicated in the repair of platinum-induced DNA lesions, including homologous repair (HR), non-homologous end joining (NHEJ), nucleotide excision repair (NER), translesion synthesis (TLS), and the Fanconi Anemia (FA) pathway.20,21 While PTX targets microtubules, it can also induce DSBs that are repaired through HR.22 We examined expression of multiple DNA repair proteins in NSCLC cells treated with CP and/or Jumonji KDM inhibitors. The gene discussed is XRCC6P5; the disease is non-small cell lung carcinoma.