MUC1 and autosomal dominant medullary cystic kidney disease with or without hyperuricemia: For example, the MUC1 gene contains a highly repetitive region with a high guanosine/cytosine content, resulting in the inability of WES and NGS panels to identify MUC1 variants, one of the most common causes of autosomal dominant tubulointerstitial kidney disease (ADTKD) [17].