In the FLAURA trial, the third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor osimertinib prolonged PFS and OS compared with erlotinib or gefitinib as first-line therapy in patients with EGFR-mutated advanced non-small cell lung cancer (NSCLC) [8]. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.