Apart from AGEs, AGER also binds to many different ligands like CML, S100s like S100A12, also called as (En-AGER), A-beta oligomers, HMGB1, LPA, CD11b/Mac1, C3a, which bind to V domain; A-Beta aggregates bind to the C1 domain and S100 A-Beta, which binds to the C2 domain in a dose-dependent manner [21, 27]. The gene discussed is ITGAM; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.