DDOST and Hyperglycemia: Hyperglycemia induced ROS overproduction is mediated by AGEs interaction with its receptors like AGE-R1 (oligosaccaharyl transferase-48), 80K-H phosphoprotein (AGE-R2) AGER1/2/3, Galectin-3 (AGE-R3), CD36, and macrophage scavenger receptor (MSR-1 and 2) is implicated in the pathogenesis of diabetic retinopathy [14, 22].