Neuropathological data were available in 16 (67%) noncases fulfilling criteria for probable sCJD; diagnoses were Alzheimer disease (AD) (7 individuals [44%]; 1 had additional dementia with Lewy body [DLB] pathology), anoxic injury (3 [16%]), CD8+ encephalitis (2 [13%]), cerebrovascular disease (1 [6%]), DLB (1 [6%]), cerebral abscess (1 [6%]) and influenza-associated necrotizing encephalopathy (1 [6%]). This evidence concerns the gene CD8A and early-onset autosomal dominant Alzheimer disease.