MRC1 and neoplasm: With respect to the expression of the MMR proteins, MLH1, MSH2, MSH6, and PMS2, loss of one or two of these proteins was found in all MSI‐H/EMAST‐positive tumours with the majority of them demonstrating loss of the MLH1/PMS2 complex, which is in good accordance with numerous studies comparing MSI‐H determined by PCR and MMRD using immunohistochemistry [31, 32, 33].