NCAPG2 and neurodevelopmental disorder: It is of further interest that recently described recessive loss-of-function mutations in NCAPG2 cause a neurodevelopmental disorder with microcephaly, and analysis of patient fibroblasts found not only abnormal chromosome condensation, but also augmented anaphase chromatin-bridge formation, similar to the anaphase-bridge formation observed in patients with BS and BLM dysfunction (44).