The cytosolic chaperonin T-complex protein 1-ring complex (TRiC), or chaperonin containing T-complex (CCT) is an oligomeric complex that promotes folding of newly synthesized polypeptides, suppresses aggregation of huntingtin in Huntington’s disease, and can inhibit assembly of α-synuclein amyloid fibrils (Lopez et al., 2015; Sot et al., 2017; Tam et al., 2009). The gene discussed is MARVELD2; the disease is juvenile Huntington disease.