IRF7 and infection: Similarly, unlike the much lower fecal shedding of virus from Mettl3ΔIEC mice vs littermate WT controls that resulted from IRF7 deficiency, the fecal viral shedding from Irf7−/−Mettl3ΔIEC mice was not significantly different from that from Irf7−/− mice (Figure 3d), suggesting that Irf7 mediates the rotavirus-infection-resistant phenotype measured by fecal viral shedding in Mettl3ΔIEC mice.