In addition, the global levels of m6A RNA modifications increased in the ileum tissue of suckling mice subsequent to infection with the RV murine strain EW (Figure 1e and f and Figure 1—figure supplement 3).By contrast m6A modification was barely detected in control IECs that had a deficiency in the m6A writer METTL3 (Mettl3fl/flVil1Cre, Mettl3ΔIEC) (Figure 1e and f). This evidence concerns the gene METTL3 and infection.