PRL-3 can dephosphorylate NHERF1 (Na+/H+ exchanger regulatory factor 1) and lead to an increase of NHERF1 and PTEN (a tumor suppressor with growth and survival regulatory functions) in the [25] cytoplasmic localization, leading to the malignant progression of melanoma [29]. The gene discussed is PTP4A3; the disease is melanoma.