Cell migration requires the integration and coordination of specific focal adhesion dynamics at the cell front, center, and rear.[2, 19] The regulation of adhesion turnover and disassembly involves a number of tyrosine kinases and phosphatases, most of which are engaged in FAK signaling pathways.[2a] To investigate the mechanisms underlying the PI3KC2α‐dependent cell migration in breast cancer cells, the relationship between PI3KC2α and focal adhesion dynamics was further explored. The gene discussed is PTK2; the disease is breast cancer.