Phosphorylation of FAK at Tyr‐397 promotes cell migration by inducing disassembly of focal adhesions at the cell tail.[23] In line with this, breast cancer cells with PI3KC2α overexpression and increased phosphorylation of Tyr‐397 displayed a significantly reduced number of focal adhesions without changes in size (Figure 2b), suggesting rapid focal adhesion turnover. Here, PTK2 is linked to breast carcinoma.