We observed that in patients with reduced PI3KC2α expression, only 26% of the tumors were scored as grade‐3 (Figure 1a, upper panel and Table 1; p<0.00001), in agreement with our findings showing that reduced PI3KC2α is initially protective in breast cancer.[12] In contrast, in the subset of patients expressing high levels of PI3KC2α, 49% of tumors were scored as grade 3 (Figure 1a, lower panels; Table 1; odds ratio, 3.03; 95% confidence interval (CI), 2.47–3.71; p<0.00001), suggesting that enhanced PI3KC2α expression was linked to increased aggressiveness and metastatic spreading.[12]. The gene discussed is PIK3C2A; the disease is breast carcinoma.