RASA3 is known to function as a dual GAP for R‐RAS and RAP1 small GTPases.[38] Here we found that, at least in breast cancer epithelial cells, overexpression of PI3KC2α leads to increased PI(3,4)P2 enrichment at focal adhesion accompanied by an increased activity of RASA3 towards R‐RAS. This evidence concerns the gene RASA3 and breast cancer.