Cell migration requires the integration and coordination of specific focal adhesion dynamics at the cell front, center, and rear.[2, 19] The regulation of adhesion turnover and disassembly involves a number of tyrosine kinases and phosphatases, most of which are engaged in FAK signaling pathways.[2a] To investigate the mechanisms underlying the PI3KC2α‐dependent cell migration in breast cancer cells, the relationship between PI3KC2α and focal adhesion dynamics was further explored. This evidence concerns the gene PIK3C2A and breast cancer.