PIK3C2A and breast cancer: For example, lack of PI(3,4)P2 alters focal adhesion dynamics in MDA‐MB‐231 breast cancer cells.[11] Similarly, class II PI3K α (PI3KC2α), a lipid kinase synthetizing PI(3,4)P2 mostly at the plasma membrane, is overexpressed and associated with poor prognosis in breast cancer.[12] Whether PI3KC2α overexpression and increased PI(3,4)P2 production in breast cancer increase metastatic spreading is unclear.