A previous study also demonstrated the clinical significance of delaying the conversion to AD in MCI patients.[18] The cognition of MCI patients may improve with specific training, as demonstrated in the Mental Activity and Resistance Training trial.[19] Our findings suggest that MCI patients in the N‐CI group may receive greater benefits from specific training approaches than those in the A‐CI group, while the A‐CI group may benefit from early clinical intervention/treatment (e.g., cholinesterase inhibitors), as they have already shown AD patterns. This evidence concerns the gene BCHE and Alzheimer disease.