Therefore, our data of expression profile and correlation analysis of mRNAs and miRNAs in hsa_circ_000839 and hsa_circ_0005986 indicated the more important role of hsa_circ_000839 in BC with the most important mRNA and miRNAs as follow: RECK, ZEB1, and BTG2 as mRNAs; and hsa‐mir‐409‐3p and hsa‐mir‐590‐5p as miRNAs. The gene discussed is BTG2; the disease is breast cancer.