However, in a cross-sectional study of 821 participants who were normal glucose tolerant and 861 participants with T2D, involving the transcription factor 7-like 2 (TCF7L2) gene [85], higher PUFA intake (mean PUFA intake of 29g/day) was linked to 1.64 mg/dl lower HDL while lower PUFA intake (mean PUFA intake of 9g/day) was associated with 1.96 mg/dl higher HDL in Asian Indian participants carrying the ‘T’ allele of the TCF7L2 SNP rs12255372 compared to those with the ‘GG’ genotype (Pinteraction<0.0001 ). Here, TCF7L2 is linked to type 2 diabetes mellitus.