TGFB1 and aneurysm: The dilated OFTs show evidence of elevated canonical TGFβ signaling, a prominent feature of aneurysm tissue in MFS and LDS patients and mouse models (Gomez et al., 2009; Habashi et al., 2006; Holm et al., 2011; Lindsay et al., 2012; Loeys et al., 2005).