Specifically, aneurysm tissue from MFS and LDS patients and genetically engineered mouse models exhibit the hallmarks of hyperactivated TGFβ signaling (Gomez et al., 2009; Habashi et al., 2006; Holm et al., 2011; Lindsay et al., 2012; Loeys et al., 2005). This evidence concerns the gene TGFB1 and aneurysm.