Collectively, the data suggest that megalin and cargo (e.g., STC1, angiotensin II, TGF-β) are shuttled from the cell surface to the mitochondria through vesicular trafficking, and it is no surprise that this shuttling pathway overlaps known vesicular trafficking defects characteristic of Lowe syndrome (retrograde early endosome to Golgi pathway) [32]. This evidence concerns the gene LRP2 and oculocerebrorenal syndrome.