Stc1: Stanniocalcin1; TGFb: TGF-b; AgII: Angiotensin II; LRP2: Megalin; OCRL1: Gene mutated in Lowe Syndrome; PIKfyve: FYVE finger-containing phosphoinositide kinase (functions along OCRL1); TGN: Trans Golgi Network; ER: Endoplasmic Reticulum. The gene discussed is OCRL; the disease is oculocerebrorenal syndrome.