ABCA3 and newborn respiratory distress syndrome: ABCA3 deficiency, an autosomal recessive disorder, and is caused by pathogenic variants in ABCA3. Biallelic variants in ABCA3 cause severe neonatal RDS, chILD, and adult pulmonary fibrosis (Shulenin et al., 2004; Klay et al., 2020; Tomer et al., 2021).