In this regard, it has been reported that inhibition of P16 could decrease the growth and metastasis potential of BC cells through inhibiting IL-6/JAK2/STAT3 signaling and that the inhibition of P16 could result in decreasing the tumor growth rate in in vivo BC xenograft models [12]. Most recently, the investigation of BC-related marker expression provided valuable results even when different types or stages of BC were studied. The gene discussed is STAT3; the disease is breast cancer.