Considering that PSA and DRE are well-established markers widely used for the diagnosis and prognosis of PCa and that PSA values ​​> 20ng/mL are associated with a greater risk of metastasis, the relationship observed between miR-338-3p and these variables suggest a protective role for miR-338-3p in disease progression. This evidence concerns the gene KLK3 and posterior cortical atrophy.