The molecular mechanism of XJDHT acting on SLE is intimately related to the key GO terms and KEGG signaling pathways, such as the react to lipopolysaccharide, membrane raft, ubiquitin-like protein ligase binding, lipid, and atherosclerosis, AGE-RAGE signaling pathway in diabetic complications, fluid shear stress, and atherosclerosis. The gene discussed is RENBP; the disease is systemic lupus erythematosus.