In summary, our results indicate that TMZ can efficiently increase the expression of ATP1α1 in myocardial tissues in mice with HF, enhance the activity and production of Na+-K+ ATPase, elevate the content of ATP, and efficiently restore and maintain the balance of K+ homeostasis within myocardial cells, thereby improving the energy metabolism of the heart and rehabilitating the balance of the myocardial microenvironment. Here, ATP1A1 is linked to hydrops fetalis.