In order to further confirm the effect of FOXA1 on endogenous SR-BI expression, we sequenced six of the human hepatoma cell lines (including 97L, 7702, 7721, Hep1, Hep3B, and HepG2), all of which were identified to be rs144334493 insertion allele homozygotes (Supplementary Figure 3), and next we used HepG2 cell line to do experiments. The gene discussed is FOXA1; the disease is hepatocellular carcinoma.