Genetic studies have demonstrated that variant of SCARB1 were associated with gene expression and plasma lipid levels (32), body mass index in white population (33), carotid intimal medial thickness (15), post-prandial lipid levels (16, 34), insulin sensitivity (16), risk of coronary heart disease (17), risk of peripheral arterial disease (35), age-related macular degeneration (36), and response to fenofibrate intervention (37). This evidence concerns the gene INS and peripheral arterial disease.