CXCR4 and coronary artery disorder: While the frequency of SWM B cells did not associate with CAD (data not shown), the expression of both CCR6 (R2 = 0.35, P < 0.001) and CXCR4 (R2 = 0.24, p = 0.001) on SWM B cells demonstrated significant correlations with CAD severity in linear regression analysis (Figures 8A,B).