Binary logistic regression analysis revealed that p-values for interactions were >0.05 for the subgroups by gender, history of DM, eGFR, and spot urine ACR, while a marginal but significant interaction existed between age and the risk of progression of CAC (p for interaction = 0.047), where a non-significant trend between low serum adiponectin level and progression of CAC was observed in the subjects with age <60 years (Supplementary Table S5). The gene discussed is ADIPOQ; the disease is diabetes mellitus.