Aerobic exercise training can induce increased mitochondrial fusion (upregulating the expression of MFN2 and OPA1 proteins) and decreased mitochondrial fission (downregulating the expression of DRP1 protein), and promote mitochondrial kinetic remodeling, effectively alleviating mitochondrial dysfunction in rats with myocardial infarction (MI) (35). This evidence concerns the gene MFN2 and myocardial infarction.