PGC-1 knockdown in mice induces cardiomyopathy via fragmentation and elongation of cardiac mitochondria, which is related to changes in mitofusin 1 (MFN1), optic atrophy 1 (OPA1), and dynamin-related protein 1 (DRP1) expression (14). The gene discussed is DNM1L; the disease is cardiomyopathy.