A retrospective study on 40 patients with severe AS identified contractile function, assessed through 2DSTE, as the only independent predictor of HF symptoms (dyspnea, angina, dizziness, and syncope upon exertion) at multivariate logistic regression (OR = 0.242, p = 0.002) including AS severity, BNP, and LV diastolic function (cut-off: LA contractile strain rate <1.01 s−1) (33). Here, NPPB is linked to hydrops fetalis.