In E-MTAB-3267 datasets, CDKL2 has a significant difference in Normal (N = 6) vs. ccRCC (N = 53), p < 0.01, was downregulated in ccRCC, the result was consistent with the GEO, ICGC, and TCGA-KIRC datasets. This evidence concerns the gene CDKL2 and nonpapillary renal cell carcinoma.