Activation of hsf-1 or overexpressing chaperones can increase longevity and stress resistance (5, 6), whereas deficiency or deregulation of hsf-1 activity is associated with accelerated aging phenotypes and neurodegenerative diseases, such as Alzheimer's disease, Huntington's disease, amyotrophic lateral sclerosis, and Parkinson's disease (7, 8). Here, HSF1 is linked to Alzheimer disease.