The aim of the present study was to investigate the presence and titer of TTV in saliva samples from asymptomatic HIV-positive individuals undergoing anti-retroviral therapy (ART), as well as in AIDS patients being treated for Kaposi's Sarcoma (AIDS-KS), and to determine if this analysis could serve as a potential biomarker of immune status, in addition to the circulating CD4+ T lymphocyte and HIV level. This evidence concerns the gene CD4 and Kaposi's sarcoma.