KLK3 and posterior cortical atrophy: Another study found that the appropriate protein combination panel (PPAP+PSA+CD63+SPHM+GLPK5) of urinary EVs also could be used for differentiating high- and low-grade PCa, which could distinguish PCa with GS ≤ 7 (3 + 4) and GS≥7 (4 + 3) well (AUC = 0.70).