In a recent meta-analysis for the diagnosis of CSA-AKI in adults by urinary TIMP-2 and IGFBP7 (25), when outcomes are restricted to KDIGO stage 1 criteria similar to our study, five studies provided a relatively low estimated AUC (AUC: 0.835; sensitivity: 0.73; and specificity: 0.76), which is comparable with our biomarker-based model (AUC: 0.84; sensitivity: 0.76; and specificity: 0.81). Here, TIMP2 is linked to acute kidney injury.