Among these [TIMP-2*IGFBP7] studies for the diagnosis of CSA-AKI in adults, only one study (27) showed prediction value of TIMP-2 and IGFBP7 at admission to ICU (AUC: 0.74; sensitivity: 0.60; and specificity: 0.88) and other positive outcomes occurred at 4 h after cardiac surgery or later (25, 27–30). The gene discussed is TIMP2; the disease is acute kidney injury.