The consequences include a decrease in chemotaxis and increase in proinflammatory interleukins, mainly IL-1 and IL-6, in addition to TNF-α, which are further increased by OS induced by hyperglycemia, causing a decrease in leukocytes proliferation and an increase in IGF-1 and ROS with decreased production of NO by monocytes/macrophages. Here, IL6 is linked to Hyperglycemia.