ACE2 and Hyperglycemia: ACE2 is a metalloproteinase with a long half-life, it can be easily glycated in patients with sustained or chronic hyperglycemia, thus favoring the formation of AGEs, mainly pentosine and CML, which have been shown to have a great participation in lung diseases with several effects such as a decrease of thrombomodulin that may be related to the disseminated vascular coagulation proposed as a mechanism involved in COVID-19, and also the elevation of D-dimer.