Although the mechanism is not well elucidated, the authors showed that NLRP1-Caspase-1 activation of caspase-6 in neurons caused neurodegeneration in hippocampal regions CA3 and DG in an AD model (Kaushal et al., 2015), implicating this pathway as a therapeutic target (Flores et al., 2021). Here, CASP1 is linked to Alzheimer disease.