After literature mining in PubMed literature retrieval system, we found that some of these 23 genes have been confirmed to be related to breast cancer, including 12 genes, ADH1A, ADH1C, AKR1C4, ALDH3A1, CYP1A2, CYP2B6, CYP2C18, CYP2C19, CYP3A4, CYP3A7, GSTA1, RXRG. The gene discussed is CYP3A4; the disease is breast cancer.