Important functional molecules that result in pyroptosis, including NLRP3, AIM2, and caspase-1, are abundantly expressed and activated in atherosclerosis and are associated with the occurrence, accumulation, and destabilization of atherosclerotic plaques (Ozaki et al., 2015; Hoseini et al., 2018; Pan et al., 2018). The gene discussed is AIM2; the disease is atherosclerosis.