However, ox-LDL-stimulated nuclear receptor subfamily 4 group A member 1 (NR4A1) overexpression caused Parkin-mediated mitophagy through the post-transcriptional modification of Ca2+/calmodulin-dependent protein kinase II, while excessive mitophagy significantly consumed mitochondrial mass, resulting in energy shortage and mitochondrial dysfunction and thus aggravating endothelial apoptosis and atherosclerosis (Li P. et al., 2018). This evidence concerns the gene NR4A1 and atherosclerosis.