However, the blockage of circular RNA serine/threonine protein phosphatase PP1-gamma catalytic subunit (circPPP1CC) relieved the Pg-LPS-induced pyroptosis of VSMCs and atherosclerosis by inhibiting the HMGB-1/TLR9/AIM2 pathway (Liu J. et al., 2021). The gene discussed is AIM2; the disease is atherosclerosis.