Caspase-1 deficiency reduces endothelial cell activation and infiltration of monocytes into intima (Gage et al., 2012; Yin et al., 2015) and attenuates ox-LDL-induced VSMC pyroptosis and IL-1β processing (Li et al., 2020), which all suppress the development of atherosclerosis. Here, CASP1 is linked to atherosclerosis.