Furthermore, the partial restoration of ciliary expression in CCA cells by inhibition of either HDAC6 or SIRT1 has been linked to decreased cell growth and migration in the tumor cells (Gradilone et al., 2013; Peixoto et al., 2020a, 2020b; Pant et al., 2021). This evidence concerns the gene SIRT1 and cholangiocarcinoma.