UCP1 and metabolic disease: To explore the potential of adipose-specific UCP1 KI pigs as models of human metabolic diseases, we compared the lipid profiles of three tissues from UCP1 KI pigs with several other published studies of metabolic disorders and muscle disease (Senoo et al., 2015; Tonks et al., 2016; Raouf et al., 2018; Haynes et al., 2019; Nylén et al., 2019).