We followed up with 16 AP patients to compare the serum USP25 level before and after treatment (Figure 1M), and the patients’ serum USP25 levels were significantly lower after treatment than that at the onset of AP (131.19 ± 42.94 pg/ml vs 90.38 ± 26.73 pg/ml, p < 0.05). Here, USP25 is linked to alkaline phosphatase measurement.