TIMP1 and cancer: CancerSEEK a multi-analyte screening test that can simultaneously detect somatic ctDNA mutations in 16 genes and quantify 8 cancer-associated proteins (carbohydrate antigen 125 (CA-125), CA19-9, CEA, HGF, myeloperoxidase, prolactin, OPN, tissue inhibitor of metalloproteinases 1 (TIMP-1)) can identify cancer in approximately 70% of PDAC patients (Cohen et al., 2018).