For example, deletion of PINK1 leads to more severe cardiac hypertrophy and left ventricle dysfunction in mice than those in wild-type and heterozygous mice (Billia et al., 2011), while Parkin-knockout mice are vulnerable to myocardial infarction induced by ligation of the proximal left anterior descending coronary artery and present a low survival rate (Kubli et al., 2013). Here, PINK1 is linked to cardiac hypertrophy.