Zhou et al. demonstrated that FUNDC1-mediated mitophagy gets activated to prevent myocardial apoptosis during ischemia, while upregulation of Ripk3 can phosphorylate Tyr18 in FUNDC1 during reperfusion to inhibit FUNDC1-dependent mitophagy and increase necrosis (Zhou et al., 2017b). The gene discussed is FUNDC1; the disease is ischemia.