For example, methyltransferase-like 3 (METTL3), the first methylase to be identified, was dysregulated in multiple malignant tumor types, including colorectal cancer (Peng et al., 2019), bladder cancer (Han et al., 2019), lung cancer (Lin et al., 2016), and melanoma (Dahal et al., 2019). Here, METTL3 is linked to urinary bladder cancer.