By inducing glycolysis-related genes products such as hexokinase 2 (HK2), lactate dehydrogenase A (LDHA), and glucose transporter 1 (GLUT1, also known as solute carrier family A1, SLC2A1), HIF-1α switches the glucose metabolism of hypoxic tumor cells to the glycolytic pathway. This evidence concerns the gene HK2 and neoplasm.