Moreover, HIF-2α, which is encoded by EPAS1 gene, having 48% homology to HIF-1α at an amino acid sequence, is expressed in many tumor cells and facilitates aerobic glycolysis by targeting and transcriptionally activating glycolysis-related genes (Warnecke et al., 2004; Kim et al., 2009; Chen et al., 2017), and promotes breast cancer cell epithelial-mesenchymal transition (EMT) and invasion (Yang et al., 2019). Here, EPAS1 is linked to breast carcinoma.