In order to elucidate the pathway by which SIPA1 modulates the expression of glycolysis-related genes and PDK1, we analyzed RNA-seq data from two pairs of breast cancer cell lines: parental and SIPA1-knowndown MDA-MB-231 cells and parental and SIPA1-overexpressing MCF7 cells. The gene discussed is PDK1; the disease is breast carcinoma.