Pura-Matrix hydrogel with MSCs applied to mouse epicardium after MI, found that it could inhibit the development of inflammation, promote the formation of myocardial capillary, reduce interstitial fibrosis, improve cardiac function and alleviate the progression of heart failure by secreting cytokines such as IL-10 (Ichihara et al., 2018). This evidence concerns the gene IL10 and myocardial infarction.