The results showed that MSCs had a strong immunosuppressive ability and inhibited lymphocyte proliferation and antibody production in vitro, and plasma cells from patients with end-stage heart failure had high IgG3 production, in vitro experiments showed that MSCs could inhibit IgG3 production, thereby preventing ventricular remodeling after MI and slowing the progression of heart failure (van den Hoogen et al., 2019). This evidence concerns the gene IGHG3 and heart failure.