Milad Riazifar and his colleagues used the autoimmune encephalomyelitis (EAE) mouse model to assess the therapeutic effects of exosomes secreted by BMMSCs in multiple sclerosis, and found that the number of CD4+, CD25+, and Forkhead box P3 (FOXP3)+ Tregs on the spinal cord of mice upregulate after intravenous injection of IFN-γ (IFN-γ-Exo)-stimulated MSCs-derived exosomes (Riazifar et al., 2019). The gene discussed is FOXP3; the disease is multiple sclerosis.