Injected MSCs overexpressing IL-10 in a mouse model of autoimmune myocarditis and found that MSCs were able to reduce the inflammatory level of the heart and the degree of myocardial fibrosis by delivering IL-10, thereby preventing and treating overactivated immune system from attacking cardiomyocytes (Shao et al., 2020). This evidence concerns the gene IL10 and Myocardial fibrosis.