In the rat model of MI, it was found that combined delivery of MSCs and MSCs-derived exosomes were able to achieve more efficient anti-inflammatory and vascular tissue repair than MSCs therapy by decreasing the expression of inflammatory factors such as IL-6 and TNF-α and increasing the expression of Recombinant Stromal Cell-Derived Factor 1 (SDF-1) (Huang et al., 2019). This evidence concerns the gene IL6 and myocardial infarction.