In the mice MI model, MSCs were injected into mice with BM-derived macrophages and found that MSCs could reduce M1 phenotypic markers (IL-6, IL-1β) and increase M2 phenotypic markers (IL-10, IL-4), and facilitated the recovery of cardiac function (Cho et al., 2014). The gene discussed is IL6; the disease is myocardial infarction.