Previous reports revealed that, in humans, HIF3A locus is significantly hypermethylated in adipose tissue of obese adults through genome-wide methylome analyses (Dick et al., 2014), modulates lypolysis (Kulyte et al., 2020), correlated with increased risk of insulin resistance and glucose metabolism (Haertle et al., 2017) and, in murine pre-adipocyte 3T3-L1 cells, Hif3α regulates WAT adipogenesis (Hatanaka et al., 2009). This evidence concerns the gene HIF3A and Insulin resistance.