RGS2 and obesity due to melanocortin 4 receptor deficiency: PreE risk factors include chronic HTN, chronic inflammatory medical conditions, obesity, family or personal history, genetic predispositions (e.g. mutations in RGS2) (Perschbacher et al., 2020), primiparity or new paternity (Li and Wi, 2000; Saftlas et al., 2003; Duckitt and Harrington, 2005), and low paternal exposure due to barrier contraceptives or a short interval between first coitus and conception (Duckitt and Harrington, 2005; Kho et al., 2009).