Similarly, intravenous immunoglobulin G administration is used as a therapy for many immune-mediated conditions, transplantation, and systemic inflammatory diseases (e.g., SLE, Guillain-Barre syndrome, RA, and more) because it inhibits DC maturation, increases anti-inflammatory IL-10, and down-regulates pro-inflammatory T cells (Bayry et al., 2003) (Figure 4). This evidence concerns the gene IL10 and rheumatoid arthritis.