Univariate analyses of the history of eczema, urticaria, allergic cough or allergic rhinitis, skin pruritus (including eye rubbing), constipation, and blood IgE levels were conducted between the OAB and control group, and the results revealed that these were significantly higher in the OAB than in control group (P < 0.05; see Table 1). This evidence concerns the gene IGHE and urticaria.