Infiltrating EBV-infected CD8+ T-cells and proliferating NK cells lead to hepatic injury and cause hepatomegaly, splenomegaly, and other clinical features, palpebral edema is related to the compression of swollen lymph nodes in the neck (Caused by lymphocyte infiltration) that makes lymphatic drainage not smooth (1). This evidence concerns the gene CD8A and Splenomegaly.