Bone fragility, craniosynostosis, ocular proptosis, hydrocephalus, and distinctive facial features including frontal bossing, midface hypoplasia, and micrognathia are a typical hallmark of Cole-Carpenter syndrome-2 (CLCRP2) (MIM# 616294), due to biallelic variants in SEC24D (125). Here, SEC24D is linked to craniosynostosis.