PTEN and Lhermitte-Duclos disease: They include Cowden syndrome (CS; OMIM# 158350), Bannayan-Riley-Ruvalcaba syndrome (BRRS; OMIM# 153480), ASD with macrocephaly, adult Lhermitte-Duclos disease, and occasionally segmental overgrowth (due to somatic PTEN mutations) (227–229).